Exercise-induced muscle pathologies

2023 – Leiberich M, Fitte A, Burroughs R, Steyl J,  Goddard A, Haw A, Boesch JM, Kohn TA and Meyer LCR. Cooling does not alter the pathophysiological consequences of capture in blesbok (Damaliscus pygargus phillipsi). Journal of Wildlife Diseases. 59(2): 288-298. DOI:10.7589/JWD-D-22-00059

2023 – Lubbe C, Meyer LCR, Kohn TA, Harvey BH,  Wolmarans D. The physiological, anatomical, and clinical features of rhabdomyolysis in wildlife and rats: towards the development of a rodent model of capture myopathy. Veterinary Research Communications. 47: 361-371. DOI: 10.1007/s11259-022-10030-9

2020 – Hohl R, Blackhurst DM, Donaldson B, Van Boom KM, Kohn TA. Wild antelope skeletal muscle antioxidant enzyme activities do not correlate with muscle fibre type or oxidative metabolism. Comparative Biochemistry and Physiology A. 242: 110638

2019 – Breed D, Meyer LCR, Steyl JCA, Goddard A, Burroughs R, Kohn TA. The biological consequences of malignant capture stress – capture myopathy. Conservation Physiology. 7(1): 559

Muscle weakness

2023 – Henning F, Kohn TA. Preservation of shortening velocity and power output in single muscle fibres from patients with idiopathic inflammatory myopathies Journal of Muscle Research and Cell Motility. 44(1):1-10. DOI: 10.1007/s10974-022-09638-w
2022 – D’Alton C, Johnstone R, du Plessis C, Pursad A, Kohn TA. The effect of systematic exercise training on skeletal muscle strength in a patient with advanced inclusion body myositis – a case study. South African Journal of Sports Medicine, 34(1). 

2020 – Henning F, Kohn TA. Contractile force production is impaired in muscle fibers from patients with inflammatory myopathies. Muscle & Nerve. 2015: 1-5.

2017 – Henning F, Cunninghame CA, Martín MA, Rubio JC, Arenas J, Lucia A, Hernández-Laín A, Kohn TA. Muscle fiber type proportion and size is not altered in McArdle disease. Muscle & Nerve, 83(Pt 6), 322-323.

2015 – Kohn TA, Noakes TD, Rae DE, Rubio JC, Santalla A, Nogales-Gadea G, Andreu AL, Martín MA, Lucia A. McArdle disease does not affect skeletal muscle fibre type profiles in humans. Biology OPEN. 3(12): 1224-1227.

Nature vs nurture

2023 – van Boom KM,  Schoeman JP, Steyl JCA,  Kohn TA. Fibre type and metabolic characteristics of skeletal muscle in 16 breeds of domestic dogs. Anatomical Record. ePub DOI: 10.1002/ar.25207

2023 – Kohn TA, Anley MJ, Magwaza SN, Adamson L, Hoffman LC, Brand TS. Muscle fiber type and metabolic profiles of four muscles from the African black ostrich. Meat Science. DOI: 10.1016/j.meatsci.2023.109156

2022 – van Boom KM, Breed D, Hughes A, Blackhurst D, Kohn TA. A novel description of the Vastus lateralis morphology of the Temminck’s Ground Pangolin (Manis temminckii). Anatomical Record. 305(12): 3463-3471. DOI: 10.1002/ar.24924

2018 – Dada S, Henning F, Kohn TA. Baboon (Papio ursinus) single fibre contractile properties are similar to that of trained humans. Journal of Muscle Research and Cell Motility. 39(5): 189-199.

2017 – Rae DE, Chin T, Dikgomo K, Hill L, McKune AJ, Kohn TA, Roden LC. One night of partial sleep deprivation impairs recovery from a single exercise training session. European Journal of Applied Physiology. 254(1), 6-14.

2014 – Santos-Concejero J, Tucker R, Myburgh KH, Essén-Gustavsson B, Kohn TA. Greater performance impairment of black runners than white runners when running in hypoxia. International Journal of Sports Medicine. 35(10), 809-816.

2014 – Kohn TA. Insights into the skeletal muscle characteristics of three southern African antelope species. Biology OPEN. 3(11), 1037-1044.

2013 – Kohn TA, Noakes TD. Lion (Panthera leo) and caracal (Caracal caracal) type IIx single muscle fibre force and power exceed that of trained humans. Journal of Experimental Biology. 216, 960-969.

2012 – Curry JW, Hohl R, Noakes TD, Kohn TA. High oxidative capacity and type IIx fibre content in springbok and fallow deer skeletal muscle suggest fast sprinters with a resistance to fatigue. Journal of Experimental Biology, 215, 3997-4005.

2011 – Kohn TA, Curry JW, Noakes TD. Black wildebeest skeletal muscle exhibits high oxidative capacity and a high proportion of type IIx fibres. Journal of Experimental Biology, 214, 4041-4047.

2011 – Kohn TA, Essén-Gustavsson B, and Myburgh KH. Specific muscle adaptations in type II fibres after high intensity interval training of well-trained runners. Scandinavian Journal of Medicine and Science in Sports, 21, 765–772.

2011 – Kohn TA, Burroughs R, Hartman MJ, Noakes TD. Fiber type and metabolic characteristics of lion (Panthera leo), caracal (Caracal caracal) and human skeletal muscle. Comparative Biochemistry and Physiology A, 159(2), 125-133.

2009 – Harley XYR, Kohn TA, Gibson A, Noakes TD and Collins M. Skeletal muscle monocarboxylate transporter content is not different between black and white runners. European Journal of Applied Physiology, 105(4), 623-632.

2007 – Kohn TA, Hoffman LC, and Myburgh KH. Identification of myosin heavy chain isoforms in skeletal muscle of four Southern African wild ruminants. Comparative Biochemistry and Physiology A, 148(2), 399-407.

2007 – Kohn TA, Essén-Gustavsson B, and Myburgh KH. Exercise pattern influences skeletal muscle hybrid fibers of runners and non-runners. Medicine and Science in Sports and Exercise, 39(11), 1977-1984.

2007 – Kohn TA, Essén-Gustavsson B, and Myburgh KH. Do skeletal muscle phenotypic characteristics of Xhosa and Caucasian endurance runners differ when matched for training and racing distances? Journal of Applied Physiology, 103, 932-940.

2005 – Kohn TA, Kritzinger B, Hoffman LC, and Myburgh KH. Characteristics of impala (Aepyceros melampus) skeletal muscles. Meat Science, 69, 277-282.

Obesity, lifestyle and insulin resistance

2023 – van Boom KH,  Kohn TA, Tordiffe ASW. A cross-over dietary intervention in captive cheetahs (Acinonyx jubatus) – investigating the effects of glycine supplementation on blood parameters. Zoo Biology. Submitted.

2020 – Leith DA, Mpofu BS, van Velden JL, Reed CC, van Boom KM, Breed D, Kohn TA. Are Cape Peninsula baboons raiding their way to obesity and type II diabetes? – a comparative study. Comp Biochem Physiol A Mol Integr Physiol 250:110794. doi:10.1016/j.cbpa.2020.110794

2020 – Webster CC, van Boom KM, Armino N, Larmuth K, Noakes TD, Smith JA, Kohn TA. Lower blood glucose clearance at rest in athletes on a low carbohydrate high fat diet may be explained by lower skeletal muscle GLUT4 and IRS1 content. International Journal of Sport Nutrition and Exercise Metabolism. -1 (aop):1-8. doi:10.1123/ijsnem.2019-0359

2016 – Webster CC, Noakes TD, Chacko SK, Swart J, Kohn TA, Smith JAH. Gluconeogenesis during endurance exercise in cyclists habituated to a long-term low carbohydrate high fat diet. Journal of Physiology, 594(15), 4389-4405.

2014 – Goyaram V, Kohn TA, Ojuka EO. Suppression of the GLUT4 adaptive response to exercise in fructose-fed rats. American Journal of Physiology. 306(3), E275-E283.

2008 – Smith JAH, Kohn TA, Chetty AK, Ojuka EO. CaMK activation during exercise is required for histone hyper-acetylation and MEF2A binding at the MEF2 site on the Glut4 gene. American Journal of Physiology, 295(3), E698-E704.

2008 – Mukwevho E, Lang D, Kohn TA, Nyatia E, Smith J, Ojuka E. Caffeine induces hyperacetylation of histones at the MEF2 site on the GLUT4 promotor and increases MEF2A binding to the site via a CaMK-dependent mechanism. American Journal of Physiology, 294, E582-588.

Technical publications

2017 – Smith JAH, McKerrow AD, Kohn TA. Metabolic cost of running differs between two types of laboratory treadmills. Journal of Sports Sciences. 35(16), 1592-1597.

2007 – Kohn TA, Myburgh KH. Regional specialisation of rat quadriceps myosin heavy chain isoforms occurring in distal to proximal parts of middle and deep regions is not mirrored by citrate synthase activity. Journal of Anatomy, 210(1), 8-18.

2006 – Kohn TA, Myburgh KH. Electrophoretic separation of human skeletal muscle myosin heavy chain isoforms: importance of reducing agents. Journal of Physiological Sciences, 56(5), 355-360.